Randall solves things. That instinct has helped him build a career, protect his family and survive enormous anxiety. If there is a problem, Randall believes there must be some combination of effort, intelligence and sacrifice capable of improving the outcome.
Rebecca's diagnosis gives him a problem that may not submit to that system. Therapy should theoretically help Randall recognize the difference between loving someone and controlling what happens to them. Instead, his fear makes the need for control stronger.
By the finale, Randall pressures Rebecca into participating in a clinical trial after she initially decides against it. He can tell himself he is fighting for his mother. The uncomfortable question is whether he has stopped allowing Rebecca to decide what fighting for herself looks like.